alexa Assessment on antioxidant activity of pomegranate seed oil in vivo


Journal of Hypertension: Open Access

Author(s): MIAO Lili, WU Haohao, QIU Nongxue, PANG Fuke

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Pomegranate seed oil extracted through aqueous enzymatic method was administered to the low-dose group,middle-dose group and high-dose group of Kunming mouse by oral gavage every day at three consecutive doses of 5,10,15 mL/(kg·bw·d),while the control group was given distilled water.After 30 days,all mices were killed through cervical dislocation,and liver and brain tissues were quickly removed and assayed for their superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) activities and malondialdehyde(MDA) contents.The results showed that SOD,GSH-PX activities in liver and brain tissues of the low-dose group were significantly higher than that of the control group(p0.05),and MDA contents in brain tissues were significantly lower than that of the control group(p0.05).It indicated that an appropriate dose of pomegranate seed oil could enhance the antioxidant function of the body,thus had an anti-aging ability.

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