alexa Association between circulating white blood cell count and long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Shankar A, Mitchell P, Rochtchina E, Tan J, Wang JJ

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Abstract Inflammatory processes are implicated in the development and progression of age-related macular degeneration (AMD). However, there are limited data on longitudinal associations between systemic markers of inflammation and AMD. The authors examined the prospective relation between the circulating white blood cell (WBC) count and early and late AMD in a population-based cohort of 3,654 participants, aged 49-97 years, in the Blue Mountains region, Australia. The main outcome of interest was the 10-year incidence of early and late AMD among individuals free from corresponding disease at the baseline (1992-1994). An elevated baseline WBC count was associated with early AMD incidence, independent of smoking and other major confounders. The multivariable relative risk comparing tertile 3 of WBC count (>6.7 x 10(9) cells/liter) with tertile 1 (
  • DOI: 10.1093/aje/kwk022
  • This article was published in Am J Epidemiol and referenced in Journal of Cytology & Histology

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