Author(s): Wen Y, Lu P, Dai L
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Abstract Epidemiological studies on the association between the single nucleotide polymorphism (SNP) at -420 C/G (rs1862513) in the human resistin gene (RETN) and the risk of type 2 diabetes mellitus (T2DM) are conflicting. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Twelve studies with 5,935 cases and 5,959 controls were enrolled by searching the databases of Medline, EMBASE, and Cochrane. Summary odds ratios (ORs) with 95\% confidence intervals (CIs) were calculated. The heterogeneity and publication bias were investigated. The main analysis indicated no significant association [for allelic model: OR = 0.97 (0.92-1.03); for additive model: OR = 0.95 (0.83-1.09); for recessive model: OR = 0.98 (0.86-1.12); for dominant model: OR = 0.95 (0.88-1.04)]. Overall, no significant heterogeneity was found. Subgroup analysis by race and source of controls indicated no significant association. In conclusion, the current meta-analysis did not observe any association between the polymorphism of RETN -420 C/G and the risk of T2DM. The study may help us further understand the genetics of T2DM. However, larger and prospective studies are warranted to confirm this finding.
This article was published in Acta Diabetol
and referenced in Endocrinology & Metabolic Syndrome