alexa Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Data Mining in Genomics & Proteomics

Author(s): Nicolas Amabile, Susan Cheng, Jean Marie Renard, Martin G Larson, Anahita Ghorbani, Elizabeth McCabe, Gabriel Griffin, Coralie Guerin, Jennifer E Ho, Stanley Y Shaw, Kenneth S Cohen, Ramachandran S Vasan, Alain Tedgui, Chantal M Boulanger, Thomas J Wang

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OBJECTIVE:

To examine the relation of endothelial microparticles (EMPs) with cardiometabolic risk in the community.

BACKGROUND:

Circulating EMPs are small membrane vesicles released after endothelial cell injury. Endothelial microparticles are reportedly increased among individuals with a high burden of cardiovascular risk factors. However, prior investigations have been limited to small, highly selected samples.

METHODS:

We studied 844 individuals without a history of cardiovascular disease in the Framingham Offspring cohort (mean age 66 ± 9 years, 57% women). We used standardized flow cytometry methods to identify and quantify circulating CD144+ and CD31+/CD41- EMPs. We then used multivariable regression analyses to investigate the relations of EMP phenotypes with cardiovascular and metabolic risk factors.

RESULTS:

In multivariable analyses, the following cardiovascular risk factors were associated with one or more of the circulating EMP populations: hypertension (P = 0.025 for CD144+,), elevated triglycerides (P = 0.002 for CD144+, P < 0.0001 for CD31+/CD41-), and metabolic syndrome (P < 0.0001 for CD144+,). Overall, each tertile increase in the Framingham risk score corresponded to a 9% increase in log-CD31+/CD41- EMPs (P = 0.022). Furthermore, the presence of hypertriglyceridaemic waist status was associated with 38% higher levels of CD144+ EMPs (P < 0.0001) and 46% higher levels of CD31+/CD41- EMPs (P < 0.0001).

CONCLUSION:

In a large community-based sample, circulating EMP levels were associated with the presence of cardiometabolic risk factors, particularly dyslipidaemia. These data underscore the potential influence of high-risk metabolic profiles on endothelial integrity.

This article was published in European Heart Journal and referenced in Journal of Data Mining in Genomics & Proteomics

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