Author(s): Delsing CE, BleekerRovers CP, van de Veerdonk FL, Tol J, van der Meer JW,
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Abstract Chronic esophageal candidiasis is an infection that is mostly seen in immunocompromised conditions, among which is chronic mucocutaneous candidiasis (CMC). Recently an association between CMC and esophageal carcinoma has been reported. Here we present two patients with chronic esophageal candidiasis who developed esophageal squamous cell carcinoma and we discuss the etiologic role of Candida-induced nitrosamine production, the loss of STAT1 function and impaired tumor surveillance and T-lymphocyte function in the development of esophageal carcinoma.
This article was published in Med Mycol Case Rep
and referenced in Journal of Integrative Oncology