alexa Association of Lung Function Indices with Inflammatory Marker (hsCRP) and Glycemic Control in Type 2 Diabetic Patients of Karachi


Advanced Practices in Nursing

Author(s): Muhammad Adnan Kanpurwala, Masood A Qureshi, Zeenat Ayoob, Zaman Shaikh

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Background/Objectives Diabetes Mellitus type 2 is a serious chronic disease with increasing prevalence throughout the world. Almost every system of the body is affected by the disease. Lung function impairment has also appeared to be a complication of diabetes. The aim of this study is to assess the difference in the lung function indices and high sensitive C-reactive protein (hsCRP) a inflammatory marker in diabetic patients as compared to the non diabetic individuals. Methodology 73 Diabetics and 77 age matched Non Diabetics’ individuals, who were non smokers and had no apparent lung diseases were recruited. All subjects underwent screening with detailed history, anthropometry, high sensitive C-reactive protein (hsCRP), glycosylated hemoglobin (HbA1c) and spirometric measurements. Results There was a significant reduction in the FVC [mean difference (95% CI) 0.495 L (0.27, 0.72) P < 0.001], FEV1 [mean difference (95% CI) 0.34 L (0.15, 0.53) P < 0.001], FEV1/FVC ratio [mean difference (95% CI) −0.018 (−0.036, −0.0003) P ≤ 0.05] and a significant increase in the hsCRP levels [mean difference (95% CI) 5.52 mg/L (3.1, 7.9) P < 0.001] in the diabetic subjects as compared to the healthy individuals. A statistical model was built using multivariable linear regression analysis to predict FVC. The model equation is as follows. FVC = β0 + β1(X1) + β2(X2) + β3(X3) + β4(X4) + β5(D). Whereas, β0 = −2.78 (constant), X1=gender, X2=height, X3=age, X4=HbA1c, D- = duration of disease >10years. R2 value = 0.77 Female gender taken as reference, Duration of disease: ≤5 years (reference), 6 – 10 years (non significant) & > 10 years Conclusion It can be concluded from this study that type 2 diabetic individuals had statistically significant lower FVC and FEV1 and raised hsCRP values as compared to the non diabetics. The effect on the FVC was even more pronounced in diabetics who had inadequate glycemic control and prolonged duration of disease. Therefore, it is suggested that clinicians should assess the diabetic patients on annual follow up for early changes in lung functions through spirometry as this would help in reducing the morbidity and mortality associated with respiratory complications

This article was published in Federation of American Societies for Experimental Biology and referenced in Advanced Practices in Nursing

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