alexa Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis.


Evidence based Medicine and Practice

Author(s): GonzlezCastro TB, TovillaZrate C, JurezRojop I, Pool Garca S, VelzquezSnchez MP, , GonzlezCastro TB, TovillaZrate C, JurezRojop I, Pool Garca S, VelzquezSnchez MP,

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Abstract BACKGROUND: The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case-control study and, to assess the combined evidence - this case-control study and available data from other related studies - we carried out a meta-analysis. METHODS: We conducted a case-control study that included 161 patients with suicide attempts and 244 controls; we then performed a meta-analysis. The following models were evaluated in the meta-analysis: A) C allele vs T allele; B) T allele vs C allele; C) Caucasian population, D) Asian population, and E) suicide attempters with schizophrenia. RESULTS: We found an association between attempted suicide and control participants for genotype (χ2=6.28, p=0.04, df=2) and allele (χ2=6.17, p=0.01, df=1, OR 1.48 95\% IC: 1.08-2.03) frequencies in the case-control study. The meta-analysis, comprising 23 association studies (including the present one), showed that the rs6313 polymorphism is not associated with suicidal behavior for the following comparisons:T allele vs C allele (OR: 1.03; 95\% CI 0.93-1.13; p(Z)=0.44); C allele vs T allele: (OR:0.99; 95\% CI: 0.90-1.08; p(Z)=0.22); Caucasians (OR:1.09; 95\% CI: 0.96-1.23), and Asians (OR:0.96; 95\% CI: 0.84-1.09). CONCLUSION: Our results showed association between the rs6313 (T102C) polymorphism and suicidal behavior in the case-control study. However, the meta-analysis showed no evidence of association. Therefore, more studies are necessary to determine conclusively an association between T102C and suicidal behavior.
This article was published in BMC Psychiatry and referenced in Evidence based Medicine and Practice

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