alexa Association of the TNF-α -308G A polymorphism with family history of type 2 diabetes mellitus in a Mexican population.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): PerezLuque E, Malacara JM, GaraySevilla ME, Fajardo ME

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Abstract AIMS: We examined the possible association of the -308G/A polymorphism of the TNF-α promoter gene in type 2 diabetes mellitus (DM2) patients and in non-diabetic subjects with and without family history of DM2. METHODS: We studied 87 non-diabetic subjects without DM2 family history in at least one of two generations, 48 non-diabetic subjects with DM2 family history and 95 DM2 patients. Genotyping was carried out by PCR-RFLP. RESULTS: The frequency of TNF-α -308G/A genotype was significantly lower in non-diabetic subjects without DM2 relatives (6\%) as compared to DM2 patients (24\%) (odds ratio (OR)=5.24; 95\% confidence interval (CI)=1.9-15.8, p<0.0005), but similar to non-diabetic subjects with DM2 relatives (29\%) (OR=0.77; CI=0.3-1.7, p=0.4). Logistic regression analysis showed the association of TNF-α -308G/A polymorphism with DM2 family history (OR=5.80; CI=1.77-18.98, p<0.0003). CONCLUSIONS: Our results suggest that TNF-α -308G/A polymorphism is associated with DM2 family history and is a risk factor for DM2. Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. This article was published in Clin Biochem and referenced in Journal of Molecular and Genetic Medicine

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