alexa Atherosclerotic plaque caps are locally weakened when macrophages density is increased.


Journal of Clinical & Experimental Cardiology

Author(s): Lendon CL, Davies MJ, Born GV, Richardson PD, Lendon CL, Davies MJ, Born GV, Richardson PD

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Abstract The density of macrophages, identified by the antibody EBMII, in human aortic plaque caps was counted. A contiguous strip of cap tissue was tested mechanically. Aortic plaque caps which had undergone rupture (ulceration) at one end (n = 18) were compared with caps of intact plaques (n = 22). The caps of ruptured plaques showed a significant increase in macrophage density, an increased extensibility and decreased maximum stress (force per unit area) at fracture when compared with caps from intact plaques.
This article was published in Atherosclerosis and referenced in Journal of Clinical & Experimental Cardiology

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