alexa Atherosclerotic plaque development and instability: a dual role for VEGF.


Anatomy & Physiology: Current Research

Author(s): Holm PW, Slart RH, Zeebregts CJ, Hillebrands JL, Tio RA

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Abstract Vascular endothelial growth factor (VEGF), a potent growth factor for endothelial cells and inducer of angiogenesis, is important for endothelial integrity and thus for vascular function. On the other hand, VEGF may enhance the pathophysiologic mechanism of plaque formation and plaque destabilization. In this review we discuss the data available so far for VEGF as angiogenic and/or inflammatory cytokine in the vulnerable atherosclerotic plaque. This article was published in Ann Med and referenced in Anatomy & Physiology: Current Research

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