alexa A-to-I RNA editing and human disease.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Maas S, Kawahara Y, Tamburro KM, Nishikura K

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Abstract The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information. As the molecular players of editing are characterized and an increasing number of genes become identified that are subject to A-to-I modification, the potential impact of editing on the etiology or progression of human diseases is realized. Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes.
This article was published in RNA Biol and referenced in Gene Technology

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