alexa Atopic dermatitis: the role of Langerhans cells in disease pathogenesis.


Journal of Clinical & Cellular Immunology

Author(s): Dubrac S, Schmuth M, Ebner S

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Abstract The manifestation of atopic dermatitis (AD) results from a complex interaction of environmental factors, skin barrier defects and immunological phenomena. The initial events in AD remain unclear while much progress has been made in identifying the mechanisms leading to the manifestation and maintenance of allergic inflammation. AD pathogenesis can be approached from many different points of view. In this review, we describe findings in mouse models and in humans separately. We focus on recent findings that underscore the importance of Langerhans cells in initial mechanisms of skin inflammation in AD. This article was published in Immunol Cell Biol and referenced in Journal of Clinical & Cellular Immunology

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