alexa ATP-driven molecular chaperone machines.
Pediatrics

Pediatrics

Pediatrics & Therapeutics

Author(s): Clare DK, Saibil HR

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Abstract This review is focused on the mechanisms by which ATP binding and hydrolysis drive chaperone machines assisting protein folding and unfolding. A survey of the key, general chaperone systems Hsp70 and Hsp90, and the unfoldase Hsp100 is followed by a focus on the Hsp60 chaperonin machine which is understood in most detail. Cryo-electron microscopy analysis of the E. coli Hsp60 GroEL reveals intermediate conformations in the ATPase cycle and in substrate folding. These structures suggest a mechanism by which GroEL can forcefully unfold and then encapsulate substrates for subsequent folding in isolation from all other binding surfaces. Copyright © 2013 Wiley Periodicals, Inc.
This article was published in Biopolymers and referenced in Pediatrics & Therapeutics

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