alexa Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Grandjean P, BudtzJrgensen E, Steuerwald U, Heinzow B, Needham LL,

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Abstract Breast-feeding has been linked to slowed postnatal growth. Although the basis for this "weanling's dilemma" is unclear, environmental contaminants in human milk may be of relevance. We studied a Faroese birth cohort of 182 singleton children, born at term in 1994-95. Concentrations of mercury in cord blood and of polychlorinated biphenyls in maternal milk were measured, and duration of breast-feeding was recorded. At 18 months, children who had been exclusively breast-fed for at least 6 months weighed 0.59 kg less [95\% confidence interval (CI) = 0.03, 1.16 kg] and were 1.50 cm [95\% CI = 0.52, 2.47 cm] shorter than those not breast-fed. However, calculated transfer of contaminants from human milk fully explained the attenuated growth. Irrespective of duration of breast-feeding, a doubling of the mercury concentration in cord blood was associated with a decrease in weight at 18 months by 0.19 kg (95\% CI = 0.03, 0.35 kg) and in height by 0.26 cm (95\% CI = -0.02, 0.55 cm). Weight and height at 42 months showed the same tendencies, but the main effect occurred before 18 months of age. Thus, in communities with increased contaminant exposures, risks associated with lactational transfer of toxicants to the infant must be considered when judging the benefits of prolonged breast-feeding. This article was published in FASEB J and referenced in Journal of Cytology & Histology

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