alexa Automated high-performance liquid chromatographic method for the determination of rifampicin in plasma.
Pharmaceutical Sciences

Pharmaceutical Sciences

Advances in Pharmacoepidemiology and Drug Safety

Author(s): KJ Swart, M Papgis

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Due to the unstable nature of rifampicin, a rapid automated high-performance liquid chromatographic method had to be developed for the analysis of a large number of plasma samples generated during a bioavailability trial. Extraction and injection of the samples were automatically done by a sample preparation system using C2, 100 mg Bond Elut extraction columns. The extracts were chromatographed on a 4-microns reversed-phase C18 column with a citrate buffer and acetonitrile as mobile phase. The analytes were detected at 342 nm. Calibration curves were linear to at least 20 micrograms/ml and the limit of quantification was 0.16 micrograms/ml.

This article was published in J Chromatogr and referenced in Advances in Pharmacoepidemiology and Drug Safety

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