alexa Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB,

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Abstract Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor. The TLR7 gene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region. These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation. This article was published in Science and referenced in Journal of Clinical & Cellular Immunology

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