alexa Autosomal dominant polycystic kidney disease.
Pathology

Pathology

Journal of Medical & Surgical Pathology

Author(s): Torres VE, Harris PC, Pirson Y

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Abstract Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal, monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which can be explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of the disorder's underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective treatments. This article was published in Lancet and referenced in Journal of Medical & Surgical Pathology

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