alexa Bacterial isolation by lectin-modified microengines.

Journal of Bioengineering and Bioelectronics

Author(s): Campuzano S, Orozco J, Kagan D, Guix M, Gao W,

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Abstract New template-based self-propelled gold/nickel/polyaniline/platinum (Au/Ni/PANI/Pt) microtubular engines, functionalized with the Concanavalin A (ConA) lectin bioreceptor, are shown to be extremely useful for the rapid, real-time isolation of Escherichia coli (E. coli) bacteria from fuel-enhanced environmental, food, and clinical samples. These multifunctional microtube engines combine the selective capture of E. coli with the uptake of polymeric drug-carrier particles to provide an attractive motion-based theranostics strategy. Triggered release of the captured bacteria is demonstrated by movement through a low-pH glycine-based dissociation solution. The smaller size of the new polymer-metal microengines offers convenient, direct, and label-free optical visualization of the captured bacteria and discrimination against nontarget cells. © 2011 American Chemical Society
This article was published in Nano Lett and referenced in Journal of Bioengineering and Bioelectronics

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