alexa Bacterial virulence: can we draw the line?
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Computer Science & Systems Biology

Author(s): Wassenaar TM, Gaastra W

Abstract Share this page

Abstract The molecular approach to microbial pathogenesis has resulted in an impressive amount of data on bacterial virulence genes. Bacterial genome sequences rapidly add candidate virulence genes to electronic databases. The interpretation of this overwhelming information is obscured because every gene involved in pathogenicity is called a virulence gene, regardless of its function in the complex process of virulence. This review summarizes the changing concept of bacterial virulence and the detection and identification strategies followed to recognize virulence genes. A refined definition of virulence genes is proposed in which the function of the gene in the virulence process is incorporated. We propose to include the life-style of bacteria in the assessment of their putative virulence genes. A universal nomenclature in analogy to the EC enzyme numbering system is proposed. These recommendations would lead to a better insight into bacterial virulence and a more precise annotation of (putative) virulence genes, which would enable more efficient use of electronic databases.
This article was published in FEMS Microbiol Lett and referenced in Journal of Computer Science & Systems Biology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version