alexa BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Thompson JS, Bixler SA, Qian F, Vora K, Scott ML,

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Abstract B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival. This article was published in Science and referenced in Journal of Clinical & Cellular Immunology

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