alexa Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease.


Journal of Clinical & Cellular Immunology

Author(s): Creed TJ, Probert CS, Norman MN, Moorghen M, Shepherd NA,

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Abstract BACKGROUND: Preliminary data have suggested that interleukin-2 receptor blockade with basiliximab may increase steroid sensitivity. We have previously reported a small case series demonstrating the potential of basiliximab as a novel agent for the treatment of steroid-resistant ulcerative colitis. AIM: To report further experience of the efficacy and safety of treatment with the interleukin-2 receptor blocking monoclonal antibody basiliximab, in addition to steroids, for the treatment of severe and moderate steroid-resistant ulcerative colitis. METHODS: Twenty patients were enrolled - 13 patients with moderate steroid-resistant ulcerative colitis (Ulcerative Colitis Symptom Score: >or=6) and seven patients with severe steroid-resistant ulcerative colitis. All were given a single dose of 40 mg basiliximab plus standard steroid therapy in an open-label, uncontrolled trial. Primary end point was clinical remission within 8 weeks (Ulcerative Colitis Symptom Score:
  • DOI: 10.1111/j.1365-2036.2006.02904.x
  • This article was published in Aliment Pharmacol Ther and referenced in Journal of Clinical & Cellular Immunology

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