alexa B-cell tolerance: mechanisms and implications.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Basten A, Silveira PA

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Abstract Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens in the B-cell repertoire. In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases. Copyright © 2010 Elsevier Ltd. All rights reserved. This article was published in Curr Opin Immunol and referenced in Journal of Genetic Syndromes & Gene Therapy

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