alexa Bcl-2 family members: essential players in skin cancer.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Nys K, Agostinis P

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Abstract Skin cancer has reached epidemic proportions and is considered to be a direct consequence of ultraviolet (UV) radiation exposure. Excessive exposure of epidermal cells to UV results in apoptosis of irreparably damaged cells to avoid malignant transformation. The Bcl-2 family of proteins is emerging as a crucial regulator of epidermal homeostasis and cell's fate in the stressed skin. Not surprisingly, deregulation of Bcl-2 family members is also chiefly involved in skin carcinogenesis and response to cancer therapy. Here we discuss the physiopathological role of epidermal Bcl-2 family members, their implications in skin carcinogenesis and as potential targets in cancer therapy. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. This article was published in Cancer Lett and referenced in Journal of Cytology & Histology

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