alexa BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.


Journal of Addiction Research & Therapy

Author(s): Kleim JA, Chan S, Pringle E, Schallert K, Procaccio V,

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Abstract Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene (BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex. This article was published in Nat Neurosci and referenced in Journal of Addiction Research & Therapy

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