alexa Beclin 1 complex in autophagy and Alzheimer disease.
Medicine

Medicine

Journal of Gerontology & Geriatric Research

Author(s): Jaeger PA, WyssCoray T

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Abstract Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be reduced in patients with Alzheimer disease. This review summarizes the current research data that link disturbances in autophagy, a cellular degradation and maintenance pathway, to the development of Alzheimer disease and related neurodegenerative diseases. It also provides a brief overview of the existing pharmacological interventions available to modulate autophagy activity in mammalian cells. This article was published in Arch Neurol and referenced in Journal of Gerontology & Geriatric Research

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