alexa Behcet's disease in Iran: analysis of 6500 cases.


Journal of Clinical & Experimental Cardiology

Author(s): Davatchi F, Shahram F, ChamsDavatchi C, Shams H, Nadji A,

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Abstract OBJECTIVE: To identify the clinical picture of Behcet's disease in a large cohort of patients (6500) in Iran, over a period of 35 years, and compare them with other large series from around the world. METHODS: Patients with Behcet's disease from all over Iran were seen in the Behcet's Disease Research Unit by a multidisciplinary team (rheumatologists, dermatologists, and ophthalmologists). Diagnosis was based on 'expert opinion'. Data were collected on a standardized data sheet (105 items), and stored in an electronic database. Data were updated at each follow-up. RESULTS: Male to female ratio was 1.22 : .00. The mean age at onset was 26 years ± 11.3. The frequency of symptoms were: oral aphthosis 97.3\%, genital aphthosis 64.6\%, skin manifestations 64.9\% (pseudofolliculitis 54.5\%, erythema nodosum 22.5\%, other lesions 7\%), pathergy phenomenon 52.5\%, ophthalmologic manifes-tations 56.8\% (anterior uveitis 41.2\%, posterior uveitis 44.9\%, retinal vasculitis 32.1\%), joint manifestations 37.4\% (arthralgia 17.2\%, monoarticular arthritis 7.6\%, oligoarthritis 16.8\%, ankylosing spondylitis 2\%), neurological manifestations 3.8\% (central manifestations 3.5\%, mononeuritis multiplex 0.3\%), gastrointestinal manifestations 7.4\%, vascular involvement 8.3\% (phlebitis 5.7\%, superficial phlebitis 2.2\%, large vein thrombosis 1.1\%, arterial thrombosis 0.154\%, aneurysm 0.5\%), epididymitis 4.7\%, cardiac involvement 0.6\%, and pulmonary involvement 0.9\%. Sedimentation rate was normal in 46.5\% of patients. Abnormal urine sediment was detected in 12.2\%. HLA-B5 was present in 53.3\% and HLA-B51 in 47.9\% of patients. CONCLUSION: Behcet's disease is mainly seen in young people. The most frequent symptoms are mucocutaneous, ocular and joint manifestations. Comparison with large series did not show major differences. This article was published in Int J Rheum Dis and referenced in Journal of Clinical & Experimental Cardiology

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