Author(s): Mathis D, Vence L, Benoist C
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Abstract The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta-cells. Apoptosis of beta-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
This article was published in Nature
and referenced in Journal of Clinical & Cellular Immunology