alexa beta-Sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle.


Journal of Food Processing & Technology

Author(s): Awad AB, von Holtz RL, Cone JP, Fink CS, Chen YC

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Abstract The present study examined the SM cycle as a mechanism to explain the inhibitory effect of SIT on HT-29 cell growth. SIT was the main phytosterol in the diet. Supplementation of SIT at 16 microM for 5 days in the media inhibited growth by 55\% as compared to cholesterol. SIT supplementation had no effect on sphingosine production. Ceramide production increased 45\% with SIT supplementation as compared to cholesterol. Sterol supplementation had no effect on phospholipase C, a key enzyme in the PKC pathway. We concluded that the activation of the SM cycle may play a role in growth inhibition of HT-29 cells by SIT.
This article was published in Anticancer Res and referenced in Journal of Food Processing & Technology

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