alexa Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
General Science

General Science

Biological Systems: Open Access

Author(s): Bozza FA, Bozza PT, Castro Faria Neto HC

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Abstract Sepsis is a major challenge in medicine. It is a common and frequently fatal infectious condition. The incidence continues to increase, with unacceptably high mortality rates, despite the use of specific antibiotics, aggressive operative intervention, nutritional support, and anti-inflammatory therapies. Typically, septic patients exhibit a high degree of heterogeneity due to variables such as age, weight, gender, the presence of secondary disease, the state of the immune system, and the severity of the infection. We are at urgent need for biomarkers and reliable measurements that can be applied to risk stratification of septic patients and that would easily identify those patients at the highest risk of a poor outcome. Such markers would be of fundamental importance to decision making for early intervention therapy or for the design of septic clinical trials. In the present work, we will review current biomarkers for sepsis severity and especially the use of cytokines as biomarkers with important pathophysiological role. This article was published in Mem Inst Oswaldo Cruz and referenced in Biological Systems: Open Access

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