Author(s): Tran DX, Sato D, Yochelis A, Weiss JN, Garfinkel A,
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Abstract Excitable cells can exhibit complex patterns of oscillations, such as spiking and bursting. In cardiac cells, pathological voltage oscillations, called early afterdepolarizations (EADs), have been widely observed under disease conditions, yet their dynamical mechanisms remain unknown. Here, we show that EADs are caused by Hopf and homoclinic bifurcations. During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments.
This article was published in Phys Rev Lett
and referenced in Journal of Physical Chemistry & Biophysics