alexa Bilirubin inhibits the TNFalpha-related induction of three endothelial adhesion molecules.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Mazzone GL, Rigato I, Ostrow JD, Bossi F, Bortoluzzi A,

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Abstract Since an increased serum unconjugated bilirubin (UCB) level has been proposed as an independent protective factor against atherosclerotic disease, we investigated the molecular events at the basis of this effect. HUVEC and H5V cells were treated with TNFalpha and UCB and the effects assessed on E-selectin, VCAM-1 and ICAM-1. In HUVEC cells, UCB blunted the TNFalpha-induced gene upregulation of E-selectin VCAM-1 and ICAM-1. The same pattern was observed in H5V cells except for ICAM-1. UCB also inhibited the PMN endothelial adhesion in HUVEC H5V cells. Western blot and FACS analysis confirmed that UCB prevented TNFalpha-induced over-expression of adhesion molecules proteins in H5V cells. These data contribute to further explain the protective effect of bilirubin against development of atherosclerosis. This article was published in Biochem Biophys Res Commun and referenced in Biochemistry & Analytical Biochemistry

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