alexa Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Unissa AN, Sudha S, Selvakumar N, Hassan S

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Abstract AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.
This article was published in Bioinformation and referenced in Journal of Diabetes & Metabolism

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