alexa Bioactive Sphingolipids and Complement Cascade as New Emerging Regulators of Stem Cell Mobilization and Homing.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Ratajczak MZ, Kim C

Abstract Share this page

Abstract The α-chemokine stromal derived factor-1 (SDF-1) - seven transmembrane span receptor CXCR4 axis plays a crucial role in retention of hematopoietic stem progenitor cells (HSPCs) in BM. However, the mechanisms that govern mobilization/release of HSPCs from bone marrow (BM) into peripheral blood (PB) and direct a reverse process of their homing back into BM microenvironment after transplantation are still poorly understood. Augmenting evidence demonstrates that during both mobilization and myeloablative conditioning for transplantation a proteolytic microenvironment is induced in BM and complement cascade (CC) becomes activated. In this review we will present augmenting evidence that as result of induction of proteolytis microenvironment as well as CC activation bioactive sphingolipids - sphingosine - 1 phosphate (S1P) and ceramide-1-phosphate (C1P) together with CC cleavage fragments (C3a, C5a and C5b-C9) orchestrate both homing and mobilization of HSCPs.
This article was published in J Stem Cell Res Ther and referenced in Journal of Stem Cell Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords