alexa Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense.
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): Freiburghaus F, Steck A, Pfander H, Brun R

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Abstract Bioassay-guided fractionation of the dichloromethane rootbark extract of Entada abyssinica (Leguminosae), a plant used by traditional healers in Uganda for the treatment of sleeping sickness, led to the isolation of a diastereoisomer of the clerodane type diterpene kolavenol. This is the first report on this compound. It showed a trypanocidal activity with an IC50 value of 2.5 microg/ml (8.6 microM) against Trypanosoma brucei rhodesiense, the causing agent of the acute form of human African trypanosomiasis.
This article was published in J Ethnopharmacol and referenced in Journal of Clinical & Experimental Pathology

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