Author(s): Duggan DE, Yeh KC, Matalia N, Ditzler CA, McMahon FG
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Abstract Bioavailabilities of dexamethasone tablets and elixir in man were evaluated by each of 3 model-independent methods of pharmacokinetic analysis employing plasma and urinary values as determined by radioimmune assay. There were no significant differences among the results determined by the 3 methods nor between the respective availabilities of the two formulations; the latter averaged 82.6 +/- 17.7\% for the elixir formulation and 78.0 +/- 12.1\% for tablets.
This article was published in Clin Pharmacol Ther
and referenced in Journal of Clinical & Experimental Pharmacology