alexa Biochemistry and molecular cell biology of diabetic complications.

Journal of Clinical Diabetes & Practice

Author(s): Brownlee M

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Abstract Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery. This article was published in Nature and referenced in Journal of Clinical Diabetes & Practice

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