Author(s): Jeddeloh JA, Fritz DL, Waag DM, Hartings JM, Andrews GP
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Abstract A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50\% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease.
This article was published in Infect Immun
and referenced in Journal of Bioterrorism & Biodefense