alexa Biogenic amine receptors in parasitic nematodes: what can be learned from Caenorhabditis elegans?
Toxicology

Toxicology

Journal of Environmental & Analytical Toxicology

Author(s): Komuniecki RW, Hobson RJ, Rex EB, Hapiak VM, Komuniecki PR, Komuniecki RW, Hobson RJ, Rex EB, Hapiak VM, Komuniecki PR

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Abstract The biogenic amines, serotonin, octopamine, tyramine and dopamine regulate many essential processes in parasitic nematodes, such as pharyngeal pumping, muscle contraction, and egg-laying, as well as more complex behaviors, such as mechanosensation and foraging, making biogenic amine receptors excellent targets for drug discovery. This review is designed to summarize our knowledge of nematode biogenic amine signaling and preliminarily identify some of the key receptors involved in the regulation of biogenic amine-dependent behaviors through an analysis of the free-living nematode, Caenorhabditis elegans. This article was published in Mol Biochem Parasitol and referenced in Journal of Environmental & Analytical Toxicology

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