alexa Biology of gangliosides: neuritogenic and neuronotrophic properties.
Neurology

Neurology

International Journal of Neurorehabilitation

Author(s): Ledeen RW

Abstract Share this page

Abstract Research on the biologic function of gangliosides has accelerated in recent years following discovery of their pronounced effects when administered exogenously to neurons in culture and in vivo. These effects are of two principal types: 1) neuronotrophic, concerned primarily with survival and maintenance of the neuron, and 2) neuritogenic, involving significant increase in the number, length, and/or branching of neuronal processes. Such neurite-promoting activity has been observed in primary cultures of neurons from brain and ganglia as well as transformed lines of neuronal origin. These phenomena may be related to the remarkable growth of aberrant secondary neurites, often accompanied by synaptogenesis, observed in the gangliosidoses. Several in vivo studies have shown exogenously administered gangliosides to aid nervous system repair in both the CNS and PNS, although it is not clear in some cases whether the observed effects should be attributed to neuronotrophic or neuritogenic effects (or both). This article attempts to briefly review the principal developments that have occurred in this area of ganglioside research over the past several years. It also presents for consideration some of the tentative hypotheses put forward concerning mechanism of action. This article was published in J Neurosci Res and referenced in International Journal of Neurorehabilitation

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords