alexa Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins.
Engineering

Engineering

Biosensors Journal

Author(s): Goldsmith BR, Mitala JJ, Josue J, Castro A, Lerner MB, , Goldsmith BR, Mitala JJ, Josue J, Castro A, Lerner MB,

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Abstract We have designed and implemented a practical nanoelectronic interface to G-protein coupled receptors (GPCRs), a large family of membrane proteins whose roles in the detection of molecules outside eukaryotic cells make them important pharmaceutical targets. Specifically, we have coupled olfactory receptor proteins (ORs) with carbon nanotube transistors. The resulting devices transduce signals associated with odorant binding to ORs in the gas phase under ambient conditions and show responses that are in excellent agreement with results from established assays for OR-ligand binding. The work represents significant progress on a path toward a bioelectronic nose that can be directly compared to biological olfactory systems as well as a general method for the study of GPCR function in multiple domains using electronic readout.
This article was published in ACS Nano and referenced in Biosensors Journal

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