alexa Bioreactor engineering of stem cell environments.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Tandon N, Marolt D, Cimetta E, VunjakNovakovic G

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Abstract Stem cells hold promise to revolutionize modern medicine by the development of new therapies, disease models and drug screening systems. Standard cell culture systems have limited biological relevance because they do not recapitulate the complex 3-dimensional interactions and biophysical cues that characterize the in vivo environment. In this review, we discuss the current advances in engineering stem cell environments using novel biomaterials and bioreactor technologies. We also reflect on the challenges the field is currently facing with regard to the translation of stem cell based therapies into the clinic. Copyright © 2013 Elsevier Inc. All rights reserved.
This article was published in Biotechnol Adv and referenced in Journal of Cell Science & Therapy

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