Author(s): Zhang F, Keasling J
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Abstract Many metabolic pathways in microbial hosts have been created, modified and engineered to produce useful molecules. The titer and yield of a final compound is often limited by the inefficient use of cellular resources and imbalanced metabolism. Engineering sensory-regulation devices that regulate pathway gene expression in response to the environment and metabolic status of the cell have great potential to solve these problems, and enhance product titers and yields. This review will focus on recent developments in biosensor design, and their applications for controlling microbial behavior. Copyright © 2011. Published by Elsevier Ltd.
This article was published in Trends Microbiol
and referenced in Journal of Microbial & Biochemical Technology
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