alexa Blood glucose is correlated with cerebrospinal fluid neurotransmitter metabolites.


Journal of Psychology & Psychotherapy

Author(s): Umhau JC, Petrulis SG, Diaz R, Rawlings R, George DT

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Abstract Medications which influence monoaminergic neurotransmission can also have an effect on glucose regulation. In order to better understand the role of central monoaminergic neurotransmission in blood glucose homeostasis, we explored the relation between blood glucose and cerebrospinal fluid metabolite concentrations of monoaminergic neurotransmitters. Under stringently controlled resting conditions, we measured fasting blood glucose and performed lumbar punctures on 41 healthy participants. Peripheral blood glucose concentrations were significantly correlated with the cerebrospinal fluid concentrations of the dopamine metabolite, homovanillic acid and the noradrenaline metabolite, 3-methoxy-4-hydroxyphenylglycol. These correlations may represent a homeostatic relation between brain neurotransmitter activity and blood glucose. Copyright 2003 S. Karger AG, Basel This article was published in Neuroendocrinology and referenced in Journal of Psychology & Psychotherapy

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