Author(s): Park IK, Morrison SJ, Clarke MF
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Abstract Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.
This article was published in J Clin Invest
and referenced in Journal of Genetic Syndromes & Gene Therapy