alexa Bone formation in cardiac valves: a histopathological study of 128 cases.
Nephrology

Nephrology

Journal of Nephrology & Therapeutics

Author(s): Steiner I, Kasparov P, Kohout A, Dominik J

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Abstract In a series of 1,177 patients with surgical valve resection, there were 128 (10.9\%) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8\%) than in women (8.5\%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely. This article was published in Virchows Arch and referenced in Journal of Nephrology & Therapeutics

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