Author(s): Steiner I, Kasparov P, Kohout A, Dominik J
Abstract Share this page
Abstract In a series of 1,177 patients with surgical valve resection, there were 128 (10.9\%) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8\%) than in women (8.5\%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely.
This article was published in Virchows Arch
and referenced in Journal of Nephrology & Therapeutics