alexa Bone matrix and mineral abnormalities in postmenopausal osteoporosis.


Vitamins & Minerals

Author(s): Burnell JM, Baylink DJ, Chestnut CH rd, Mathews MW, Teubner EJ

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Abstract Iliac crest biopsies from 56 postmenopausal osteoporotic females with spontaneous compression fractures and decreased total body Ca were compared to similar tissue from 48 normal controls. Biopsies were analyzed for bone density, Na, Ca, Mg, P, Co3, and hydroxyproline (OH-P). From the results OH-P/matrix, \% mineral, and the ion content of the mineral were calculated. osteoporotic subjects showed decreased bone density, \% mineral in bone, and OH-P in the bone matrix. Within the mineral, CO3 and Ca/P were decreased, while Na and Mg were increased. Statistical analysis showed that matrix OH-P and \% mineral varied independently, and therefore the patients were separated into 4 subgroups: Group Ia: decreased matrix OH-P with normal \% mineral (n = 9), Group Ib: decreased matrix OH-P with decreased \% mineral (n = 5), Group IIa: normal matrix OH-P with normal \% mineral (n = 33), Group IIb: normal matrix OH-P with decreased \% mineral (n = 9). Decreased \% mineral was associated with decreased bone density and an increase in Na and Mg in the mineral, which suggests skeletal Ca deficiency. Decreased matrix OH-P was associated with decreased bone density and, in the low \% mineral group, with decreased mineral CO3 and Ca/P, suggesting a mineral of decreased mean crystal size. When both abnormalities coexisted (Group Ib), the greatest reduction in total body Ca was seen. Patients with normal matrix and normal \% mineral (Group IIa) still had decreased bone density. The results suggest that in a large, clinically homogeneous population of postmenopausal osteoporotic women, 4 subgroups can be identified by differences in chemical composition of iliac crest biopsies.
This article was published in Metabolism and referenced in Vitamins & Minerals

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