alexa Boronate-mediated biologic delivery.
Materials Science

Materials Science

Journal of Nanomedicine & Biotherapeutic Discovery

Author(s): Ellis GA, Palte MJ, Raines RT

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Abstract Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells. © 2012 American Chemical Society
This article was published in J Am Chem Soc and referenced in Journal of Nanomedicine & Biotherapeutic Discovery

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