alexa Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S.--a SEER analysis.
Healthcare

Healthcare

Journal of Womens Health Care

Author(s): Kakarala M, Rozek L, Cote M, Liyanage S, Brenner DE

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Abstract BACKGROUND: Recent reports suggest increase in estrogen receptor (ER), progesterone receptor (PR) negative breast cancer yet little is known about histology or receptor status of breast cancer in Indian/Pakistani women.in the U.S. METHODS: We examined the United States National Cancer Institute's Surveillance Epidemiology and End Results (SEER) Cancer program to assess: a) frequency of breast cancer by age, b) histologic subtypes, c) receptor status of breast cancer and, d) survival in Indians/Pakistanis compared to Caucasians. There were 360,933 breast cancer cases diagnosed 1988-2006. Chi-Square analyses and Cox proportional hazards models, to estimate relative risks for breast cancer mortality after adjusting for confounders, were performed using Statistical Analysis Software 9.2. RESULTS: Among Asian Indian/Pakistani breast cancer patients, 16.2\% were < 40 yrs. old compared to 6.23\% in Caucasians (p < 0.0001). Asian Indian women had more invasive ductal carcinoma (69.1 vs. 65.7\%, p < 0.0001), inflammatory cancer (1.4\% vs. 0.8, p < 0.0001) and less invasive lobular carcinoma (4.2\% vs. 8.1\%, p < 0.0001) than Caucasians. Asian Indian/Pakistani women had more ER/PR negative breast cancer (30.6\% vs. 21.8\%, p = 0.0095) than Caucasians. Adjusting for stage at diagnosis, age, tumor grade, nodal status, and histology, Asian Indian/Pakistani women's survival was similar to Caucasians, while African Americans' was worse. CONCLUSIONS: Asian Indian/Pakistani women have higher frequency of breast cancer (particularly in age < 40), ER/PR negative invasive ductal and inflammatory cancer than Caucasians.
This article was published in BMC Cancer and referenced in Journal of Womens Health Care

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