alexa Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.


Journal of Antimicrobial Agents

Author(s): Darrell E Hurt

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Therapeutic agents brequinar sodium and leflunomide (Arava™) work by binding in a hydrophobic tunnel formed by a highly variable N-terminus of family 2 dihydroorotate dehydrogenase (DHODH). The X-ray crystallographic structure of an analog of brequinar bound to human DHODH was determined. In silico screening of a library of compounds suggested another subset of brequinar analogs that do not inhibit human DHODH as potentially effective inhibitors of Plasmodium falciparum DHODH.

This article was published in Bioorganic & Medicinal Chemistry Letters and referenced in Journal of Antimicrobial Agents

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