alexa Brick by brick: metabolism and tumor cell growth.
Molecular Biology

Molecular Biology

Journal of Cell Science & Therapy

Author(s): Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB

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Abstract Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect'). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.
This article was published in Curr Opin Genet Dev and referenced in Journal of Cell Science & Therapy

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